Related Experiment Video
Updated: Jul 13, 2026
Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
Deep learning-based effusion-synovitis volume measured on MRI is associated with osteoarthritis progression: A
Adrian A Marth1,2,3, Felix Liu1, Ethan Pan1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
Objective:
To investigate whether the 48-month change in effusion-synovitis volume (ΔESV) is associated with concurrent knee osteoarthritis progression, and to compare these associations with those of semiquantitative change in effusion-synovitis using the MRI Osteoarthritis Knee Score (ΔMOAKS).
Design:
In this study using data from the Osteoarthritis Initiative conducted from 02/2004-10/2015, deep learning-based measurements of knee ESV were derived from baseline and 48-month follow-up knee MRI (n = 2469). OA outcomes included change of Kellgren-Lawrence (KL) grade, Whole-Organ Magnetic Resonance Imaging Score (WORMS) and its subscales (meniscus, bone marrow edema-like lesions [BMELL], cartilage), and symptom progression by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Associations of ESV change (ΔESV) with OA outcome changes were evaluated using spline-based regression models. Effect sizes were reported as interdecile differences (IDDs; 90th vs 10th percentile of the exposure). To compare the associations between ΔESV and ΔMOAKS, differences in IDD (ΔIDD) were estimated.
Results:
ΔESV was significantly associated with ΔKL grade, ΔWORMSTotal, ΔWORMSMeniscus, ΔWORMSBMELL, ΔWORMSCartilage, and ΔWOMAC (all p < 0.001). Compared with ΔMOAKS, ΔESV demonstrated significantly stronger associations for ΔKL grade (ΔIDD = 0.22; p = 0.002), ΔWORMSTotal (ΔIDD = 0.21; p = 0.008), and ΔWORMSMeniscus (ΔIDD = 0.20; p = 0.026), whereas differences were non-significant for ΔWORMSBMELL (p = 0.51), ΔWORMSCartilage (p = 0.25), or ΔWOMAC (p = 0.19).
Conclusions:
Longitudinal change in ESV was associated with concurrent imaging-based and symptomatic osteoarthritis progression over 48 months. Compared with changes in MOAKS scores, ΔESV showed stronger associations with imaging-based OA outcomes. These findings underscore the potential of MRI-based ΔESV as an osteoarthritis imaging biomarker, while further studies are needed to establish its predictive and clinical utility.
