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Related Experiment Video

Updated: Jul 14, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

Peri-Operative Systemic Inflammatory Responses Predict Post-Operative Complications in Patients Undergoing Pelvic

Tin-Ning Wong1, Chia Yew Kong1,2, Peter Ishak1,2

  • 1Academic Unit of Surgery and Lister Department of Surgery, Glasgow Royal Infirmary, University of Glasgow, Glasgow, UK.

Journal of Surgical Oncology
|July 12, 2026
PubMed
Summary

High post-operative C-reactive protein (CRP) levels on day 3 predict complications after pelvic exenteration surgery. This finding aids in early detection and management of post-surgical issues in advanced rectal cancer patients.

Keywords:
beyond total mesorectal excisionpelvic exenterationperi‐operative systemic inflammatory responseprimary locally advanced colorectal cancer

Related Experiment Videos

Last Updated: Jul 14, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

Area of Science:

  • Oncology
  • Surgical Oncology
  • Inflammatory Response

Background:

  • Systemic inflammatory response (SIR) impacts outcomes in colorectal surgery.
  • The role of SIR in pelvic exenteration (PE) surgery is not well-defined.

Purpose of the Study:

  • To investigate the association between peri-operative SIR biomarkers and post-operative complications in pelvic exenterative surgery.
  • To evaluate C-reactive protein (CRP) as a predictor of complications following PE.

Main Methods:

  • Retrospective cohort study of 114 patients undergoing PE or beyond total mesorectal excision (bTME) for advanced sigmoid and rectal cancers.
  • Analysis of clinicopathological variables, complications, and SIR biomarkers (CRP, albumin, mGPS, neutrophils).
  • Firth's penalized logistic regression used to assess SIR biomarkers and post-operative CRP as predictors of complications.

Main Results:

  • Major and infective complications occurred in 25.4% and 43.0% of patients, respectively.
  • Pre-operative high modified Glasgow Prognostic Score (mGPS) and neutrophilia were associated with adverse factors.
  • Post-operative-day-3 (POD3) CRP > 150 mg/L independently predicted major (OR 7.40) and infective (OR 2.42) complications.

Conclusions:

  • POD3 CRP > 150 mg/L is a significant predictor of peri-operative morbidity after pelvic exenteration.
  • This biomarker allows for dynamic stratification of risk and facilitates early detection of complications.
  • Targeted management strategies can be implemented based on POD3 CRP levels.