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Prehabililtation in Retroperitoneal Sarcomas.

Eyal Mor^1,2, Hayden Snow^1,2, Jenelle Loeliger^2,3

¹Division of Cancer Surgery, The Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.

Journal of Surgical Oncology

|July 12, 2026

Summary

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Multimodal prehabilitation programs for retroperitoneal sarcoma (RPS) patients are feasible. This approach may reduce high-risk patient complications following complex RPS surgery.

Area of Science:

Oncology
Surgical Oncology
Prehabilitation Medicine

Background:

Retroperitoneal sarcoma (RPS) surgery is complex and associated with significant post-operative morbidity.
Prehabilitation strategies aim to enhance patient physical, psychological, and nutritional status before high-risk surgery.
This study evaluates a multimodal prehabilitation program implemented for RPS patients.

Purpose of the Study:

To assess the feasibility and outcomes of a multimodal prehabilitation program for patients undergoing retroperitoneal sarcoma resection.
To describe the characteristics of patients enrolled in the prehabilitation program and their peri-operative results.

Main Methods:

Retrospective analysis of 41 patients who underwent RPS resection and participated in a prehabilitation program between 2020 and 2023.

Keywords:

Surgical Oncology prehabililtation retroperitoneal sarcoma

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The prehabilitation program incorporated physical, nutritional, and psychological support components.

Data collected included pre-operative assessments (e.g., cardiopulmonary exercise testing, AKPS, MST score) and peri-operative outcomes (e.g., operative time, hospital/ICU stay, complications).

Main Results:

Forty-one patients completed the prehabilitation program, with an average duration of 57 days.
Pre-operative assessments revealed an average peak VO2 of 14.9 ml/kg/min and an Australia-modified Karnofsky Performance Status (AKPS) of 85.
Major post-operative complications (Clavien-Dindo ≥ 3) occurred in 21% of patients, with 4% requiring re-operation.

Conclusions:

A multimodal prehabilitation program for retroperitoneal sarcoma patients is feasible.
The program shows potential benefits for high-risk patients undergoing complex RPS surgery, warranting further investigation.