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The adhesion G protein-coupled receptor F5 (ADGRF5) as an architect of immune response in cancers

Damian Jacenik1

  • 1University of Lodz, Faculty of Biology and Environmental Protection, Department of Cytobiochemistry, Lodz, Poland.

Biochimica Et Biophysica Acta. Reviews on Cancer
|July 12, 2026
PubMed

Insights

Adhesion G protein-coupled receptor F5 (ADGRF5) impacts cancer cell aggression and the tumor microenvironment. Targeting ADGRF5 offers potential for novel immunooncology therapies by modulating cancer immunity.

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Adhesion G protein-coupled receptor F5 (ADGRF5) is implicated in cellular homeostasis and disease.
  • ADGRF5 plays a dual role in cancer, affecting both cancer cells and the tumor microenvironment.

Purpose of the Study:

  • To review the role of ADGRF5 in cancer and immunity.
  • To explore the translational potential of ADGRF5 in immunooncology.

Main Methods:

  • Literature review of ADGRF5 expression and signaling in cancer.
  • Analysis of experimental data on ADGRF5's impact on cancer and immune cells.
  • Evaluation of ADGRF5's therapeutic potential in immunooncology.

Main Results:

  • ADGRF5 drives cancer cell aggressiveness.
  • ADGRF5 orchestrates the tumor microenvironment.
  • ADGRF5 is crucial for cancer-related immunity.

Conclusions:

  • ADGRF5 is a key regulator in cancer immunity.
  • ADGRF5 presents a promising target for immunooncology therapeutics.
Keywords:
ADGRF5GPR116Immune responseNK cellT cellTumor microenvironment

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