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Related Experiment Video

Updated: Jul 14, 2026

Bioreactor Assembly for Continuous Culture of Complex Fecal Communities

Bioreactor Assembly for Continuous Culture of Complex Fecal Communities

Published on: April 25, 2025

Bioinspired microcapsule reactor with engineered probiotics for IBD therapy.

Minhui Xu¹, Yuanchun Du², Guangfu Feng³

¹College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, China.

Nature Communications

|July 12, 2026

Summary

Engineered bacteria in bionic microcapsules effectively treat inflammatory bowel disease by sensing inflammation and releasing therapeutic peptides, improving gut health and reducing systemic inflammation.

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Area of Science:

Biomedical Engineering
Microbiology
Immunology

Background:

Probiotic bionic strategies for inflammatory bowel disease (IBD) face challenges like poor survival and targeting.
Coral reef defense mechanisms inspire a novel bionic approach.

Purpose of the Study:

To develop a core-shell bionic microcapsule reactor (MY-E@SS) for effective IBD therapy.
To create an intelligent platform for modulating inflammatory microenvironments.

Main Methods:

Developed MY-E@SS encapsulating engineered bacteria.
Tested delivery and therapeutic efficacy in a male murine model of IBD.
Investigated mechanisms including TNF-α/NF-κB signaling pathway inhibition.

Main Results:

MY-E@SS ensured safe delivery and colonization of engineered bacteria.
The system responsively released anti-inflammatory peptides at inflamed sites.
Demonstrated significant therapeutic efficacy: restored gut barrier, reduced inflammation and oxidative stress, modulated metabolism, and reestablished microbial balance.

Conclusions:

The bionic microcapsule platform offers a promising strategy for IBD treatment.
This intelligent system effectively modulates inflammatory microenvironments for complex diseases.