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Association between dietary total antioxidant capacity and ulcerative colitis severity: a cross-sectional study
Seyyed Morteza Seyyed Shoura1, Reza Mahdavi2, Zahra Bakhtiari3
1Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Scientific Reports
|July 12, 2026
Summary
Dietary antioxidants may reduce ulcerative colitis (UC) severity. Higher dietary total antioxidant capacity (DTAC) was linked to a lower likelihood of active UC, suggesting antioxidant-rich diets could aid UC management.
Area of Science:
- Gastroenterology
- Nutritional Science
- Inflammatory Bowel Disease Research
Background:
- Ulcerative colitis (UC) is increasingly influenced by dietary habits.
- Antioxidants are hypothesized to mitigate UC-related inflammation.
- The role of dietary total antioxidant capacity (DTAC) in UC management requires investigation.
Purpose of the Study:
- To investigate the association between dietary total antioxidant capacity (DTAC) and the severity of ulcerative colitis (UC).
Main Methods:
- A cross-sectional study involving 158 UC patients at Imam Reza Hospital, Tabriz, Iran.
- Dietary intake assessed via food frequency questionnaire; DTAC calculated using the ferric reducing antioxidant power (FRAP) method.
- UC severity measured by Mayo Score; statistical analyses included ANOVA and adjusted logistic regression.
Main Results:
- Significant demographic and dietary variations observed across DTAC tertiles.
- Higher DTAC tertiles correlated with increased employment, marriage rates, and intake of calories, protein, and carbohydrates.
- Adjusted logistic regression revealed significantly decreased odds of active UC in the highest DTAC tertile (OR: 0.27; P=0.023).
Conclusions:
- Higher dietary antioxidant capacity is associated with lower ulcerative colitis severity.
- Antioxidant-rich diets show potential for managing UC.
- Further longitudinal studies are warranted to confirm this association.
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