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Related Experiment Video

Updated: Jul 14, 2026

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
07:51

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

De-epithelialized gingival unit graft for gingival phenotype modification and root coverage: a randomized controlled

Zeki Kacar1, Ezgi Gurbuz2, Mehmet Meric Ersoz1

  • 1Department of Periodontology, Faculty of Dentistry, Kutahya Health Sciences University, Kutahya, Turkey.

Clinical Oral Investigations
|July 12, 2026
PubMed
Summary

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The de-epithelialized gingival unit graft (DUG) showed superior results in root coverage and gingival thickness compared to the de-epithelialized gingival graft (DGG) for treating gingival recession defects. DUG offers a promising alternative for enhancing soft tissue thickness.

Area of Science:

  • Periodontology
  • Regenerative Dentistry
  • Oral Surgery

Background:

  • Gingival recession defects require effective treatment for root coverage and aesthetic improvement.
  • Gingival phenotype modification is crucial for long-term periodontal health.
  • Coronally advanced flap (CAF) procedures are commonly used, often combined with grafts.

Purpose of the Study:

  • To compare the efficacy of de-epithelialized gingival unit graft (DUG) versus de-epithelialized gingival graft (DGG) in conjunction with CAF for treating single gingival recession defects.
  • To evaluate outcomes related to gingival thickness, root coverage, and patient-reported measures.

Main Methods:

  • A randomized controlled trial involving 15 patients with bilateral RT1 gingival recession defects.
  • Surgical sites were randomly assigned to receive either DUG or DGG with CAF.
Keywords:
Connective tissueGingivaGingival recessionPhenotypePlastic surgery

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Last Updated: Jul 14, 2026

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Published on: January 12, 2019

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  • Clinical, linear, and volumetric digital measurements, including gingival thickness and root coverage, were assessed at 6 months.

    • Main Results:

    • The DUG group demonstrated significantly greater increases in gingival thickness (2.39 mm vs. 1.66 mm) and digital linear dimensions (1.66 mm vs. 1.13 mm) compared to the DGG group (p<0.01).
    • Mean root coverage was higher in the DUG group (95%) than the DGG group (75%), although not statistically significant.
    • Graft thickness was significantly greater in the DUG group (p=0.027). Postoperative pain and bleeding showed no significant differences between groups.

    Conclusions:

    • DUG appears to provide superior outcomes for gingival phenotype modification and root coverage compared to DGG in treating gingival recession defects.
    • The baseline difference in graft thickness may be a confounding factor, requiring cautious interpretation.
    • DUG presents a viable alternative for cases with limited recipient soft tissue thickness.