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Related Experiment Video

Updated: Jul 14, 2026

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

Nuclear dysfunction in aging and neurodegeneration.

Abbigael Aday^1,2,3, Jack Tiller^1,2,3, Adarsh Melukote^3,4

¹Department of Neurology, University of Texas Medical Branch, Galveston, Texas, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|July 12, 2026

Summary

Nuclear dysfunction plays a key role in neurodegenerative diseases, impacting neuronal integrity. Targeting nuclear structure and function may offer new therapeutic strategies for these conditions.

Keywords:

aging dementia neurodegeneration nuclear dysfunction nucleocytoplasmic transport protein aggregation

Related Experiment Videos

Last Updated: Jul 14, 2026

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

Area of Science:

Neuroscience
Cell Biology
Genetics

Background:

Neurodegenerative diseases involve neuronal loss and dysfunction due to factors like protein buildup and inflammation.
Understanding common mechanisms is challenging due to interconnected cellular components (cytosol, cytoskeleton, nucleus).

Purpose of the Study:

To review the role of nuclear dysfunction in aging and neurodegenerative disease progression.
To explore how nuclear alterations contribute to neuronal vulnerability.

Main Methods:

Review of emerging evidence on nuclear structure and function in neurodegeneration.
Analysis of alterations in nuclear architecture, chromatin, nucleocytoplasmic transport, DNA damage, and inflammation.

Main Results:

Changes in nuclear structure and function are critical drivers, not just consequences, of neurodegeneration.
Nuclear dysfunction involves alterations in chromatin, transport, DNA repair, and inflammatory signaling.

Conclusions:

Nuclear dysfunction is a significant factor in neuronal impairment and neurodegeneration.
Therapies targeting nuclear integrity are needed to combat neurodegenerative diseases.