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Resolution of Paediatric Cow's Milk Allergy Is Associated With Low Tfh Cell Frequencies and Elevated IL-17 and IL-22

Guillaume Lezmi1,2, Celine Dietrich1, Marie-Alexandra Alyanakian3,4

  • 1Team Immunity in Health and Disease, Institut Necker Enfants Malades, Inserm UMR-S1151, CNRS UMR-S8253, Université Paris Cité, Paris, France.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|July 13, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
T cellschildrencytokinesfood allergytolerance

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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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