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An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
High-Grade Serous Carcinoma of the Ovary: A Case Report
Farah Jiandani1, Savita Somalwar1, Anuja Bhalerao1
1Department of Obstetrics and Gynaecology, N.K.P. Salve Institute of Medical Sciences and Research Centre, Nagpur, IND.
Abstract:
Ovarian cancer (OC) is one of the most common gynecological cancers, representing the abnormal and uncontrolled growth of ovarian cells leading to the formation of tumors. It is one of the leading causes of death in the majority of nations. A wide range of factors, such as lifestyle, environmental factors, genetic factors, hormonal changes, and repeated miscarriages, influence the emergence of OC. Contrary to these factors, breastfeeding, pregnancy, oral contraceptive pills (OCP), and tubal ligation lower the risk of getting OC. The classification of OC as early-stage, advanced-stage, low-grade, or high-grade cancer mainly depends on the histological subtype present at the time of detection. There are various classification systems used to classify OC, but the two most commonly used ones are the International Federation of Gynaecology and Obstetrics (FIGO) staging system and the tumor-node-metastasis (TNM) staging system. The present case is of a 63-year-old female patient diagnosed with high-grade serous carcinoma of the ovary with a TNM staging grade of T1a N0 M0 and an FIGO A1 grade, managed effectively with staging laparotomy. The case study concludes that early identification and care of OC can prevent disease progression, resulting in a better quality of life and prolonging the patient's life. It is crucial to conduct frequent evaluations of a specific age group in the older population to avoid such occurrences.

