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Updated: Jul 14, 2026

Standardized Methods for Measuring Induction of the Heat Shock Response in Caenorhabditis elegans
Published on: July 3, 2020
The heat shock factor Cbr-HSF-1 is necessary for lifespan maintenance in C. briggsae
Harvir Bhullar1, Jordan Dias1, Khushi Pastagia1
1Biology, McMaster University, Hamilton, ON, CA.
Abstract:
The heat shock response is a conserved mechanism that plays a critical role in organismal survival under thermal stress. Caenorhabditis briggsae is a widely used model organism for comparative studies involving its well-known cousin C. elegans and exhibits increased thermotolerance under heat stress. In C. elegans , the transcription factor HSF-1 has been well characterized for its role in many processes including development, thermotolerance, and lifespan. We recently showed that Cbr- hsf-1 is necessary for fertility and protection against heat stress. Here, we report that Cbr- hsf-1 also plays essential roles during development and adulthood to maintain the lifespan of animals. .
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