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Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

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Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
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Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease III: Interprofessional Care

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Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Related Experiment Videos

PREDICT Tool for Pregnancy-Associated CKD Progression.

Elizabeth Ralston1, Mairéad Hamill1, Shalini Santhakumaran2

  • 1Department of Women and Children's Health, Faculty of Life Sciences and Medicine, School of Life Course and Population Sciences, King's College London, London, UK.

Kidney International Reports
|July 13, 2026
PubMed
Summary

New models predict adverse pregnancy outcomes for women with chronic kidney disease (CKD). These tools help patients and doctors make informed decisions about pregnancy risks and kidney health.

Keywords:
chronic kidney diseaseobstetric nephrologyprediction tool

Related Experiment Videos

Area of Science:

  • Nephrology
  • Obstetrics
  • Reproductive Medicine

Background:

  • Prepregnancy counseling is crucial for women with chronic kidney disease (CKD) due to potential adverse outcomes.
  • Currently, no validated tools exist to estimate individual pregnancy risks for women with CKD.

Purpose of the Study:

  • To develop and externally validate two prediction models for adverse pregnancy outcomes in women with CKD.
  • To prioritize outcomes important to both CKD patients and healthcare professionals.

Main Methods:

  • Utilized linked data from UK registries (RaDar, UKRR, HES) for model development.
  • Included women with eGFR < 90 ml/min/1.73 m² preconception, with deliveries between 1997-2021.
  • Validated models using independent cohorts from Ontario, Canada, and UK studies.

Main Results:

  • Developed models with high sensitivity and negative predictive value for predicting a ≥25% eGFR reduction or kidney replacement therapy (KRT) postpartum.
  • Identified optimal risk cut-points: 0.15 for the primary kidney outcome and 0.10 for the secondary neonatal outcome.
  • External validation confirmed the models' high performance in predicting adverse kidney outcomes.

Conclusions:

  • Successfully developed high-performing prediction models for adverse kidney and neonatal outcomes in pregnancies complicated by CKD.
  • These individualized risk assessment tools can empower expectant parents and clinicians in making informed decisions.
  • The models offer a significant advancement in managing pregnancy in women with chronic kidney disease.