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Related Experiment Video

Updated: Jul 14, 2026

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
08:42

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

Continuous flash suppression responses in mouse visual cortex: Stimulus laterality and anesthesia effects.

Mathis Bassler1, Lilian Emming1, Christopher J Whyte2,3

  • 1Department of Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.

Iscience
|July 13, 2026
PubMed
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Binocularly conflicting stimuli suppress visual cortex responses in mice, with suppression depending on stimulus laterality. Awake mice showed response recovery, unlike anesthetized ones, suggesting distinct processing.

Area of Science:

  • Neuroscience
  • Visual Processing
  • Sensory Systems

Background:

  • Binocular vision involves integrating information from both eyes.
  • Binocular rivalry and suppression are phenomena where conflicting visual stimuli lead to altered perception and neural responses.
  • Understanding these processes in animal models is crucial for deciphering human visual perception.

Purpose of the Study:

  • To investigate if binocularly conflicting stimuli induce binocular response suppression in the mouse visual cortex.
  • To examine neuronal responses in visual areas V1 and LM using a continuous flash suppression paradigm.
  • To determine the effect of stimulus laterality and animal state (awake vs. anesthetized) on visual processing.

Main Methods:

  • Presentation of adapted continuous flash suppression stimuli to awake and anesthetized mice.
Keywords:
binocular rivalrybinocular suppressioncontinuous flash suppressionmouse visual cortex

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  • Recording neuronal responses in visual areas V1 and LM.
  • Modulation of responses to monocular gratings by conflicting stimuli presented to the fellow eye.

    • Main Results:

    • Neuronal responses to monocular gratings were suppressed by conflicting stimuli, with suppression direction dependent on grating laterality.
    • Cells preferring ipsilateral gratings showed strong suppression.
    • Similar modulations occurred under anesthesia, but only awake mice exhibited response recovery after intermittent conflict.

    Conclusions:

    • Mouse binocular conflict processing shows a distinct laterality dependency, affecting responses to both gratings and Mondrian stimuli.
    • Awake state is critical for response recovery following binocular conflict.
    • A canonical binocular rivalry model fits the data but does not capture oscillatory activity under conflict.