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Radiologic and Lipid Metabolism Imaging Features Associated with FABP2 Expression in Clear Cell Renal Cell Carcinoma:

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Clear cell renal cell carcinoma (ccRCC) with fatty acid-binding protein 2 (FABP2) expression shows a less aggressive, lipid-rich phenotype. Computed tomography (CT) features weakly correlate with FABP2, offering noninvasive radiogenomic insights.

Keywords:
adipose tissueclear cell renal cell carcinomaradiogenomics

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Area of Science:

  • Oncology
  • Radiology
  • Genomics

Background:

  • Investigating the link between computed tomography (CT) imaging characteristics and fatty acid-binding protein 2 (FABP2) gene expression in clear cell renal cell carcinoma (ccRCC).
  • Focusing on morphologic and metabolic parameters detectable via CT scans.

Purpose of the Study:

  • To determine the association between CT features and FABP2 gene expression in ccRCC.
  • To explore whether imaging can noninvasively predict FABP2 status and its correlation with tumor aggressiveness.

Main Methods:

  • Retrospective analysis of 246 ccRCC patients from TCGA and TCIA.
  • Classification of patients into FABP2-positive (23.17%) and FABP2-negative (76.83%) groups.
  • Quantitative CT analysis of tumor attenuation and abdominal fat, alongside logistic regression modeling using radiologic and metabolic parameters.

Main Results:

  • FABP2-positive ccRCC tumors were smaller, lower-grade, and diagnosed earlier.
  • FABP2-negative tumors showed more collateral vascular supply.
  • Lower mean tumor attenuation in FABP2-positive tumors indicated higher intracellular lipid content.
  • Lipid metabolism model (AUC 0.61) slightly outperformed radiologic model (AUC 0.58), with mean tumor attenuation being the key predictor.

Conclusions:

  • FABP2-positive ccRCC exhibits a less aggressive, lipid-rich phenotype.
  • CT attenuation is weakly associated with FABP2 expression, providing potential noninvasive radiogenomic insights.
  • Findings support integrated radiogenomic approaches for ccRCC characterization.