Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Managing nusinersen therapy during pregnancy in spinal muscular atrophy type 3.

BMJ case reports·2026
Same author

Reevaluating the Effectiveness of Intracranial Pressure Monitoring in Severe Traumatic Brain Injury: Influence of Withdrawal of Life-Sustaining Treatments.

Neurosurgery·2026
Same author

2D Semiconductor Nanosheets Supported on Colloidal Quantum Cubes.

ACS nano·2026
Same author

Cultural, Societal, and Behavioral Contributors to Delays in Seeking Care for Postmenopausal Bleeding Among Disaggregated Populations of Black Women.

International journal of environmental research and public health·2026
Same author

Surgical Treatment of Radiation-Induced Brachial Plexus Neuropathy in Breast Cancer Patients after Adjuvant Radiotherapy: A Systematic Review.

Indian journal of orthopaedics·2026
Same author

Clinical Reasoning: A 41-Year-Old Man Presenting With Right Foot Tingling.

Neurology·2026

Related Experiment Video

Updated: Jul 14, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Intermuscular coherence as a candidate biomarker for primary lateral sclerosis.

Naoum P Issa1, Elena Badillo-Goicoechea1, Serdar Aydin1

  • 1Department of Neurology, University of Chicago Medical Center, Chicago, IL, USA.

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
|July 13, 2026
PubMed
Summary

Intermuscular coherence (IMCβγ) and its imaginary component (ICOHβγ) show promise as accessible biomarkers for upper motor neuron (UMN) dysfunction in Primary Lateral Sclerosis (PLS). Lower coherence levels in PLS patients suggest potential for early diagnosis.

Keywords:
IMCIntermuscular coherencePLSimaginary coherenceprimary lateral sclerosis

More Related Videos

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Related Experiment Videos

Last Updated: Jul 14, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Area of Science:

  • Neurophysiology
  • Biomarker Discovery
  • Neuromuscular Disorders

Background:

  • Upper motor neuron (UMN) dysfunction requires reliable and accessible neurophysiological biomarkers.
  • Primary Lateral Sclerosis (PLS) is a rare UMN disease lacking definitive diagnostic markers.

Purpose of the Study:

  • To investigate intermuscular coherence in the beta-gamma frequency range (IMCβγ) and its imaginary component (ICOHβγ) as potential biomarkers for PLS.
  • To assess the diagnostic accuracy of IMCβγ and ICOHβγ in differentiating PLS patients from neurotypical controls.

Main Methods:

  • IMCβγ and ICOHβγ were measured in upper and lower limb muscle pairs of 21 PLS patients and 42 controls.
  • Clinical evaluations included deep tendon reflex assessment and manual muscle strength testing.
  • Receiver operating characteristic (ROC) curve analysis was used to determine diagnostic performance.

Main Results:

  • IMCβγ and ICOHβγ were significantly reduced in PLS patients compared to controls in both arms and legs.
  • ROC analysis showed areas under the curve ranging from 0.71 to 0.77 for single-limb measurements.
  • A diagnostic test using abnormal coherence in any two limbs achieved 0.76 sensitivity, 0.86 specificity, and 0.83 accuracy for PLS.

Conclusions:

  • IMCβγ in arms and ICOHβγ in legs effectively distinguish PLS patients from neurotypical individuals.
  • These coherence measures demonstrate potential as accessible biomarkers for UMN dysfunction in PLS.
  • Further validation may establish IMCβγ and ICOHβγ as valuable tools in diagnosing and monitoring PLS.