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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
Association Between Sustained Frailty Remission and All-Cause and Cause-Specific Mortality: A Prospective Cohort
Yonghao Xiao1, Ziwang Zhou1, Min Jin1
1Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Summary
Sustained frailty remission in older adults is linked to reduced mortality risk. Achieving sustained frailty remission may improve survival outcomes, particularly for cancer mortality.
Area of Science:
- Gerontology
- Public Health
- Epidemiology
Background:
- Frailty is a dynamic condition in older adults, with potential for reversibility.
- The long-term prognostic impact of sustained frailty remission is not well understood.
Purpose of the Study:
- To investigate the association between sustained frailty remission and mortality.
- To analyze the impact on all-cause, cardiovascular disease (CVD), and cancer-specific mortality.
Main Methods:
- Analysis of 4,580 participants aged 50+ from the SHARE study.
- Classification of frailty trajectories (remain pre-frail/frail, remain robust, sustained remission).
- Utilized Cox models to assess mortality risks over a median follow-up of 100 months.
Main Results:
- Sustained remission was associated with lower all-cause mortality (HR=0.81) and cancer mortality (HR=0.61) compared to remaining pre-frail/frail.
- No significant association was found with cardiovascular disease mortality (HR=0.73).
- Individuals remaining robust had the lowest all-cause mortality risk (HR=0.52).
Conclusions:
- Sustained frailty remission is associated with improved survival, particularly reducing cancer mortality.
- Maintaining a robust state offers the greatest survival benefit.
- Further research may explore interventions to promote frailty remission.
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