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Updated: Jul 14, 2026
10:27
Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
Published on: December 5, 2019
RNF126 in Physiology and Disease: A Multifunctional RING-Type E3 Ubiquitin Ligase in Protein Homeostasis, DNA Repair,
Anh Duc Vu1,2, Shiori Mori1, Takeharu Sakamoto1
1Department of Cancer Biology, Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan.
Cells
|July 13, 2026
Summary
Ring finger protein 126 (RNF126) is a crucial E3 ubiquitin ligase involved in protein quality control and DNA repair. It plays complex roles in various diseases, including cancer, acting as both an oncogene and tumor suppressor.
Area of Science:
- Biochemistry
- Molecular Biology
- Cellular Biology
Background:
- Ring finger protein 126 (RNF126) is a RING-type E3 ubiquitin ligase.
- It regulates cellular homeostasis, stress adaptation, and disease progression.
- RNF126 possesses distinct zinc-finger and catalytic RING domains for substrate recognition and ubiquitin transfer.
Purpose of the Study:
- To review the current knowledge on RNF126 structure and function.
- To summarize its physiological and pathological roles.
- To discuss therapeutic strategies targeting RNF126.
Main Methods:
- Literature review of existing studies on RNF126.
- Analysis of RNF126's role in protein quality control (PQC) and DNA damage response (DDR).
- Examination of RNF126's involvement in cancer and other diseases.
Main Results:
- RNF126 is essential for PQC, cooperating with chaperones like BAG6.
- It regulates key DDR pathways (homologous recombination, non-homologous end joining) via substrates like MRE11 and Ku80.
- RNF126 acts as an oncogene in many cancers by degrading tumor suppressors (p21, PTEN, p53), promoting proliferation and metastasis.
Conclusions:
- RNF126 has context-dependent functions, acting as an oncogene or tumor suppressor.
- It is implicated in diverse pathologies including neurodegeneration, cardiac disease, and immune regulation.
- Targeting RNF126 presents potential therapeutic strategies for precision medicine.
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