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Related Experiment Video

Updated: Jul 14, 2026

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Methotrexate for hand osteoarthritis.

Divya Vohora1, Samuel L Whittle2,3, Renea V Johnston3

  • 1Department of Pharmacology, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, India.

The Cochrane Database of Systematic Reviews
|July 13, 2026
PubMed
Summary

Methotrexate may offer benefits for hand osteoarthritis, but its safety and effectiveness require thorough evaluation. This review assesses methotrexate

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Area of Science:

  • Rheumatology
  • Pharmacology
  • Clinical Trials

Background:

  • Osteoarthritis (OA) is a degenerative joint disease.
  • Hand OA significantly impacts quality of life.
  • Current treatments for hand OA have limitations.

Purpose of the Study:

  • To evaluate the efficacy and safety of methotrexate in managing hand osteoarthritis.
  • To synthesize evidence from randomized controlled trials on methotrexate for hand OA.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials.
  • Search of major biomedical databases for relevant studies.
  • Assessment of study quality and risk of bias.

Main Results:

  • Data on methotrexate's impact on pain, function, and structural changes in hand OA are limited.
  • Adverse events associated with methotrexate use need careful monitoring.
  • Evidence regarding long-term benefits and harms is still emerging.

Conclusions:

  • Methotrexate's role in hand OA management requires further investigation.
  • More high-quality research is needed to establish definitive recommendations.
  • Individualized treatment decisions should consider potential benefits and risks.