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Related Experiment Video

Updated: Jul 14, 2026

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure
04:05

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure

Published on: June 30, 2023

Airway Risk in Angioedema: Validation of a Clinical Triage Algorithm for ENT Referral.

Dan Yaniv1,2, Igor Vainer1,2, Dean Dudkiewicz1,2

  • 1Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|July 13, 2026
PubMed
Summary

A new triage algorithm can safely identify patients with angioedema who do not need nasopharyngoscopy, reducing unnecessary ear, nose, and throat (ENT) consultations while ensuring airway safety.

Keywords:
airway distressangioedemafiberoptic laryngeal examinationnasopharyngoscopyurticaria

Related Experiment Videos

Last Updated: Jul 14, 2026

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure
04:05

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure

Published on: June 30, 2023

Area of Science:

  • Emergency Medicine
  • Otolaryngology
  • Allergy and Immunology

Background:

  • Angioedema can present with laryngeal involvement, posing a risk to airway patency.
  • Nasopharyngoscopy is often used to evaluate laryngeal edema in angioedema patients.
  • Overutilization of specialist consultations can strain healthcare resources.

Purpose of the Study:

  • To identify clinical predictors of laryngeal involvement in angioedema patients.
  • To develop and validate a triage algorithm for nasopharyngoscopic evaluation in the emergency department (ED).
  • To assess the algorithm's impact on reducing ear, nose, and throat (ENT) referrals.

Main Methods:

  • Retrospective review of angioedema patients undergoing fiberoptic laryngeal (FOL) examination in the ED.
  • Analysis of demographic, clinical, and endoscopic data to identify predictors of laryngeal edema.
  • Development and temporal validation of a multivariable logistic regression-based triage algorithm.

Main Results:

  • Laryngeal edema was present in 8.5% of the derivation cohort (n=540).
  • Independent predictors of laryngeal involvement included age >50, shortness of breath, uvular edema, and prior angioedema history; lip swelling was protective.
  • The validated algorithm could have avoided ENT referrals for 81.4% of patients in the validation cohort (n=43) without compromising airway safety, estimating an 80% reduction in consultations.

Conclusions:

  • A simple triage algorithm incorporating age, shortness of breath, uvular edema, prior episodes, and lip swelling can guide the need for nasopharyngoscopy in angioedema.
  • This algorithm may significantly decrease unnecessary ENT consultations.
  • The approach appears safe, not compromising airway management in patients with angioedema.