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Updated: Jul 14, 2026
05:07
Characterizing Extracellular Vesicles from Biological Fluids
Published on: February 28, 2025
Extracellular Vesicles in Stroke: Drivers of Brain-Body Network Crosstalk
Zhi-Ming Xu1, Yu-Jia Jin1, Wei-Qing Zhang2
1Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Translational Stroke Research
|July 13, 2026
Summary
Extracellular vesicles (EVs) are key messengers linking brain injury and body responses in stroke. Understanding EV roles in stroke pathology and recovery is crucial for developing new therapeutic strategies.
Area of Science:
- Neuroscience
- Vascular Biology
- Cell Biology
Background:
- Stroke is increasingly viewed as a complex brain-body network disorder.
- Extracellular vesicles (EVs) act as intercellular messengers, connecting vascular injury, neuroinflammation, and systemic responses.
- EVs can transfer molecular cargo, influencing pathology across the brain-body axis.
Purpose of the Study:
- To review evidence on how EV programs encode and propagate stroke pathology.
- To discuss the role of EVs in vascular etiologies, intra-CNS communication, and systemic complications of stroke.
- To explore analytical standards, clinical EV signatures, and translational strategies for stroke research.
Main Methods:
- Integration of clinical and experimental evidence from diverse studies.
- Analysis of EV composition and intercellular communication pathways.
- Review of emerging analytical standards and translational frameworks.
Main Results:
- EVs are implicated in coupling vascular injury, neuroinflammation, and systemic responses in stroke.
- EVs can reach the central nervous system (CNS) via blood-brain barrier (BBB) disruption or active transport.
- EV programs may encode and propagate stroke pathology, influencing recovery trajectories.
Conclusions:
- EVs represent a critical link in the brain-body network disorder of stroke.
- Distinguishing stroke-specific EV signals from generic injury responses is essential for clinical applications.
- Modulating EV pathways holds potential for influencing stroke recovery and developing novel therapeutic interventions.
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