Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linking circulating chemerin and adiponectin to lipoprotein subclasses measured by <sup>1</sup>H-NMR spectroscopy in 3199 participants from the study of health in Pomerania.

International journal of obesity (2005)·2026
Same author

Urinary Iodine Quantification in Epidemiological Studies: Optimization in Sample Preparation of the Sandell-Kolthoff Method.

ACS omega·2026
Same author

Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms.

Nature communications·2026
Same author

DNA methylation signatures of bilateral hippocampal volume, asymmetry and atrophy: a cross-omics analysis in the general population.

EBioMedicine·2026
Same author

Definition, Classification, Diagnostics and Differential Diagnostics of Diabetes Mellitus: Update 2025.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2026
Same author

Thyroid hormones are associated with pituitary and thyroid volume in a population-based study.

Journal of the Endocrine Society·2026

Related Experiment Video

Updated: Jul 14, 2026

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy
07:54

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy

Published on: December 15, 2011

Urinary Metabolic Age from High-Resolution NMR Reveals Longitudinal Aging Patterns.

Karen Friederike Gauß1,2, Nele Friedrich1,3, Ann-Kristin Henning1

  • 1Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|July 13, 2026
PubMed
Summary

Biological age, reflecting genetic and environmental aging influences, can be estimated using urinary metabolites. This metabolic age score predicts disease and mortality, offering insights into aging heterogeneity.

Keywords:
biological agehigh resolution 1H NMRmachine learningurinary metabolomics

More Related Videos

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

Related Experiment Videos

Last Updated: Jul 14, 2026

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy
07:54

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy

Published on: December 15, 2011

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

Area of Science:

  • Metabolomics
  • Gerontology
  • Biomarkers

Background:

  • Biological age reflects individual aging rates influenced by genetics and environment.
  • Metabolites integrate genetic and environmental factors, making them suitable for biological age estimation.
  • Urinary metabolomics offers a non-invasive method to assess systemic metabolic states.

Purpose of the Study:

  • To develop a biological age score using urinary NMR metabolites and machine learning.
  • To evaluate longitudinal metabolic age trajectories.
  • To assess associations of metabolic age with clinical phenotypes, diseases, and mortality.

Main Methods:

  • Applied machine learning to high-resolution 1H NMR urinary metabolite data from a large cohort.
  • Calculated a metabolic age score.
  • Examined cross-sectional and longitudinal associations with aging phenotypes and outcomes.

Main Results:

  • Metabolic age progression varied significantly among individuals, highlighting aging heterogeneity.
  • The metabolic age score showed plausible associations with age-related clinical phenotypes.
  • Metabolic age predicted incident diseases and all-cause mortality independently of chronological age.

Conclusions:

  • Urinary metabolomics provides a robust, non-invasive approach for biological age assessment.
  • Metabolic age trajectories offer insights into inter-individual aging differences.
  • Urinary metabolic age is a promising tool for risk stratification and aging research.