Related Experiment Video
Updated: Jul 15, 2026
04:26
Postoperative Ileus Murine Model
Published on: July 12, 2024
Characterization of Patient-Reported Loin Pain in IgAN.
Kristina L Newman1,2, Jonathan Barratt1,3, Justyna Szklarzewicz1,3
1Mayer IgA Nephropathy Research Group, Division of Cardiovascular Sciences, School of Medical Sciences, University of Leicester, Leicester, UK.
Kidney International Reports
|July 13, 2026
Summary
Loin pain affects over 70% of IgA nephropathy (IgAN) patients, impacting their wellbeing and receiving limited support. Further research is needed for effective pain management strategies in IgAN.
Area of Science:
- Nephrology
- Pain Management
- Patient Reported Outcomes
Background:
- Loin pain is a common but poorly understood symptom in IgA nephropathy (IgAN).
- Limited data exists on its prevalence, characteristics, and impact on patients' daily lives.
- Current management strategies and patient support for loin pain in IgAN are insufficient.
Purpose of the Study:
- To investigate the prevalence, characteristics, and impact of loin pain in IgA nephropathy (IgAN) patients.
- To explore the association of loin pain with chronic kidney disease (CKD) stage and systemic symptoms.
- To assess the perceived support from healthcare professionals (HCPs) for managing loin pain.
Main Methods:
- A UK-wide mixed-methods study involving an online survey of 358 IgAN patients and semistructured interviews with 21 patients.
- Survey data analyzed using descriptive statistics and group mean comparisons.
- Interview data analyzed using reflexive thematic analysis.
Main Results:
- Loin pain was highly prevalent (70.9%) among surveyed IgAN patients.
- Pain was predominantly described as aching and intermittent, independent of CKD stage.
- Patients experiencing recent pain reported poorer health, mental health, and self-efficacy, with limited HCP support.
Conclusions:
- Loin pain is a significant and prevalent issue for IgA nephropathy patients in the UK.
- The pain negatively impacts psychosocial wellbeing, with inadequate support from healthcare professionals.
- There is a clear need for improved understanding and management strategies for loin pain in IgAN.
More Related Videos
Related Concept Videos
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:17Assessment of the Gastrointestinal System I: Subjective Data
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems related to...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems related to...
01:19Abdominal Regions and Quadrants
To promote clear communication, for instance, about the location of a patient's abdominal pain or a suspicious mass, anatomists and clinicians typically use imaginary lines to categorize the abdominopelvic cavity into either four quadrants or nine regions to identify organs in the cavity.
The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersects at the patient's umbilicus (navel). The four quadrants...
The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersects at the patient's umbilicus (navel). The four quadrants...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.