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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Myocardial Infarction and Functional Outcome Assessment in Pigs
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Published on: April 25, 2014

Integrated left ventricular geometry-function phenotypes and long-term outcomes after acute myocardial infarction.

Seonmin Park1, Seok Oh2, Yongwhan Lim2

  • 1Department of Cardiology, Presbyterian Medical Center, Jeonju, Republic of Korea.

Frontiers in Cardiovascular Medicine
|July 13, 2026
PubMed
Summary

Left ventricular dilatation after acute myocardial infarction (AMI) poses a higher risk only when systolic function is reduced. Integrated assessment of left ventricular geometry and function improves risk stratification beyond ejection fraction alone.

Keywords:
acute myocardial infarctionechocardiographyleft ventricular remodelingoutcomesprognosis

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Published on: April 17, 2021

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Clinical Medicine

Background:

  • Left ventricular (LV) remodeling post-acute myocardial infarction (AMI) significantly impacts long-term patient outcomes.
  • The interplay between LV geometry and systolic function in predicting prognosis after AMI requires further investigation in diverse populations.

Purpose of the Study:

  • To investigate the combined prognostic impact of LV dilatation and systolic dysfunction in patients following AMI.
  • To determine if LV dilatation alone or in conjunction with reduced ejection fraction influences major adverse cardiac and cerebrovascular events (MACCE).

Main Methods:

  • Analysis of 19,664 patients with AMI from Korean nationwide multicenter registries.
  • Phenotyping based on LV end-diastolic dimension (LVEDD) for dilatation and LV ejection fraction (LVEF) for systolic function.
  • Utilized multivariable Cox proportional hazards models to assess the association between geometry-function phenotypes and 3-year MACCE.

Main Results:

  • The incidence of MACCE increased progressively across phenotypes: non-dilated/preserved (13.2%), dilated/preserved (13.5%), non-dilated/reduced (16.8%), and dilated/reduced (21.9%).
  • LV dilatation was not significantly associated with increased risk in patients with preserved LVEF.
  • LV dilatation was associated with a significantly higher risk of MACCE when combined with reduced LVEF.

Conclusions:

  • The prognostic significance of LV dilatation after AMI is contingent upon the underlying systolic function.
  • LV dilatation in the context of reduced LVEF identifies a high-risk patient phenotype.
  • Integrated assessment of LV geometry and function offers enhanced risk stratification beyond LVEF alone.