Related Experiment Video

Updated: Jul 15, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Factors associated with cognitive developmental delay risk in 12-month-old infants

Yanping Zhang1, Wei Li2, Xiaochun He3

  • 1School of Nursing, Chengdu Medical College, Chengdu, Sichuan, China.

Frontiers in Pediatrics
|July 13, 2026
PubMed

Insights

Infant cognitive development risk is linked to factors like delivery method, maternal health, and caregiving. Early screening for these risks can guide interventions for better developmental outcomes.

Area of Science:

  • Pediatric developmental neuroscience
  • Public health
  • Maternal and child health

Background:

  • Cognitive developmental delay in infants poses significant long-term health challenges.
  • Early identification of risk factors is crucial for timely intervention.
  • Understanding modifiable factors can inform preventative strategies.

Purpose of the Study:

  • To identify perinatal, familial, and caregiving factors associated with cognitive developmental delay in 12-month-old infants.
  • To provide evidence supporting early risk screening and intervention strategies.

Main Methods:

  • A case-control study involving 762 twelve-month-old infants was conducted.
  • Infants were screened using the Denver Developmental Screening Test (DDST).
  • Logistic regression analysis was used to evaluate perinatal, family, and caregiving factors.

Main Results:

  • Cesarean delivery, maternal alcohol use during pregnancy, pre-pregnancy overweight/obesity, and abnormal gestational weight gain were identified as independent risk factors.
  • Grandparental caregiving was also associated with increased risk.
  • Higher paternal education and household income were found to be protective factors.

Conclusions:

  • Cognitive developmental risk at 12 months is associated with various perinatal, familial, and caregiving factors.
  • Comprehensive assessment of modifiable factors can aid in identifying infants at risk.
  • Findings support targeted early prevention and intervention strategies for improved infant development.
Abstract

Keywords:
12-month-old infantscesarean deliverycognitive developmental delay riskmaternal obesitysocioeconomic status

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