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ATP attenuates olaparib-induced gastric damage in rats
Mesud Fakirullahoglu1, Ayetullah Temiz1, Mustafa Yeni1
1Department of General Surgery, Erzurum City Hospital, Erzurum, Türkiye.
Background:
Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor widely used in cancer therapy, has been associated with gastrointestinal adverse effects; however, the underlying mechanisms remain unclear. Previous studies have suggested that oxidative stress may contribute to olaparib-induced tissue injury.
Objective:
This study aimed to investigate the protective effects of adenosine triphosphate (ATP) against olaparib-induced gastric damage in rats.
Methods:
Animals were divided into healthy control (HG), olaparib alone (OLPG), ATP alone (ATPG), and ATP + olaparib (ATOLG) groups. Gastric injury was evaluated by macroscopic assessment of ulcer area and ulcer number. Histopathological alterations were examined using hematoxylin-eosin (H&E) staining, and oxidative stress status was assessed by measuring lipid peroxidation and antioxidant defense parameters.
Results:
Olaparib administration induced marked gastric mucosal injury, characterized by increased ulcer area and ulcer number, severe histopathological damage, and pronounced oxidative stress. In contrast, ATP co-administration significantly attenuated gastric injury, as evidenced by reduced ulcer area and ulcer number, improved histopathological architecture, and restoration of oxidative balance. Compared with the OLPG group, the ATOLG group showed significant improvement in macroscopic, histopathological, and oxidative stress parameters.
Conclusion:
ATP administration attenuated olaparib-induced gastric damage and improved oxidative stress parameters in rats. Although the underlying mechanisms were not directly investigated in the present study, the obtained findings provide preliminary experimental evidence suggesting that ATP may have protective potential against olaparib-induced gastric injury.
Insights
Adenosine triphosphate (ATP) protected against gastric damage caused by olaparib, a cancer drug. This study in rats suggests ATP may reduce side effects like ulcers and oxidative stress.
Area of Science:
- Gastroenterology
- Oncology
- Pharmacology
Background:
- Olaparib, a PARP inhibitor used in cancer therapy, can cause gastrointestinal issues.
- The exact mechanisms behind olaparib-induced gastric damage are not fully understood.
- Oxidative stress is a potential contributor to olaparib-induced tissue injury.
Purpose of the Study:
- To investigate the protective effects of adenosine triphosphate (ATP) against olaparib-induced gastric damage in a rat model.
- To assess if ATP can mitigate the gastrointestinal adverse effects associated with olaparib treatment.
Main Methods:
- Rats were divided into four groups: healthy control, olaparib alone, ATP alone, and ATP + olaparib.
- Gastric injury was assessed macroscopically (ulcer area and number) and histopathologically (H&E staining).
- Oxidative stress markers, including lipid peroxidation and antioxidant parameters, were measured.
Main Results:
- Olaparib induced significant gastric mucosal injury, characterized by ulcers and histopathological damage.
- Olaparib treatment led to pronounced oxidative stress in the gastric tissue.
- Co-administration of ATP markedly reduced gastric injury, improved tissue architecture, and restored oxidative balance compared to olaparib alone.
Conclusions:
- ATP administration attenuated olaparib-induced gastric damage in rats.
- ATP improved oxidative stress parameters, suggesting a protective role against olaparib's gastrointestinal toxicity.
- These findings provide preliminary evidence for ATP's potential therapeutic benefit in managing olaparib-related gastric injury.
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