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Related Experiment Video

Updated: Jul 15, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

Structured Cap-assisted Margin Assessment Reduces Residual Neoplasia after Colorectal Polypectomy: A Prospective

Alexander Huelsen1, Timothy Willis2, Prabha Ketheson3,4

  • 1Department of Gastroenterology and Digestive HealthGold Coast University HospitalSouthportQueenslandAustralia.

Endoscopy International Open
|July 13, 2026
PubMed
Summary

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A new structured cap-assisted resection margin assessment (CARMA) protocol significantly reduced residual colorectal neoplasia after endoscopic resection. This method improves polyp removal and may lower recurrence rates.

Area of Science:

  • Gastroenterology and Endoscopy
  • Colorectal Cancer Prevention
  • Surgical Oncology

Background:

  • Recurrence of colorectal polyps after endoscopic resection is common.
  • Variability in operator technique contributes to inconsistent outcomes.
  • Need for standardized methods to ensure complete polyp resection.

Purpose of the Study:

  • To evaluate a structured cap-assisted resection margin assessment (CARMA) protocol.
  • To standardize near-field inspection and margin clearance during polyp resection.
  • To assess the impact of CARMA on residual neoplasia and recurrence rates.

Main Methods:

  • Prospective multicenter study involving 48 medium-to-large non-pedunculated colorectal polyps (≥10 mm).
  • Conventional snare resection followed by CARMA with targeted resection of margin abnormalities.
Keywords:
diagnosis and imaging (inc chromoendoscopy, NBI, iSCAN, FICE, CLE...)endoscopic resection (polypectomy, ESD, EMRc, ...)endoscopy lower GI tractpolyps/adenomas/...tissue diagnosis

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Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

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Last Updated: Jul 15, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
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Published on: May 10, 2021

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
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  • Histologic validation using circumferential cold-snare resection (CS360); primary outcome: residual neoplasia.

    • Main Results:

    • CARMA identified residual neoplasia in 50% of polyps after conventional resection.
    • After CARMA-targeted resection, residual neoplasia decreased to 6.3% (p=9.5 × 10^-7).
    • No recurrence observed at 6-month surveillance; adverse events were absent.

    Conclusions:

    • Structured CARMA protocol significantly reduces histology-confirmed residual neoplasia.
    • CARMA demonstrates potential for standardizing margin assessment and improving resection quality.
    • Further evaluation in larger studies is warranted for margin-focused inspection strategies.