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Evaluation of Aortic Dilation in Patients With Hypertrophic Cardiomyopathy in a Tertiary Center for Cardiovascular

Tahereh Babaei1,2, Kosar Babaei3, Golnaz Houshmand4

  • 1Department of Cardiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, iums.ac.ir.

Cardiology Research and Practice
|July 13, 2026
PubMed

Insights

Aortic dilation affects over a quarter of hypertrophic cardiomyopathy (HCM) patients, linked to age and hypertension. Early aortic evaluation in HCM is crucial for managing this complication.

Area of Science:

  • Cardiology
  • Genetics
  • Vascular Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease.
  • Aortic dilation is an underrecognized complication of HCM.
  • This study investigates aortic dilation prevalence and risk factors in HCM.

Purpose of the Study:

  • Determine the prevalence of aortic dilation in HCM patients.
  • Identify clinical and echocardiographic factors associated with aortic dilation.
  • Assess the relationship between aortic dilation and myocardial fibrosis.

Main Methods:

  • Retrospective analysis of 216 adult HCM patients.
  • Exclusion of patients with valvular disease, aortic anomalies, or other cardiomyopathies.
  • Collection of clinical, echocardiographic, and cardiac MRI data; logistic regression for factor identification.

Main Results:

  • 26.3% of patients had ascending aorta dilation; 5.6% had sinus of Valsalva (SOV) dilation.
  • Ascending aorta dilation associated with older age, hypertension, increased BSA, and LVESD.
  • Independent predictors for ascending aorta dilation: age, hypertension, LVESD, and right ventricular hypertrophy.

Conclusions:

  • Aortic dilation is common in HCM patients.
  • Associated with age, hypertension, and cardiac remodeling.
  • Routine aortic evaluation in HCM patients is recommended for early detection and management.
Abstract

Keywords:
aortic dilationechocardiographyhypertrophic cardiomyopathysinus of Valsalva dilation

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