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Updated: Jul 15, 2026
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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Metachronous contralateral pheochromocytoma detected 62 years after initial surgery
Yoshie Kawabe1, Kuniaki Ozaki1, Aki Niinomi1
1Department of Diabetes and Endocrinology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
JCEM Case Reports
|July 13, 2026
Summary
This case report details a pheochromocytoma diagnosed 62 years after initial surgery, the longest reported interval. It emphasizes lifelong surveillance for neuroendocrine tumors like pheochromocytoma and paraganglioma.
Area of Science:
- Endocrinology
- Oncology
- Surgical Oncology
Background:
- Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors with malignant potential.
- While surgery can be curative, long-term surveillance is crucial due to risks of recurrence, metastasis, or new tumor development, often decades later.