Related Experiment Video
Updated: Jul 15, 2026

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
Published on: November 29, 2024
Sequential Biologic, Small-Molecule, and GLP-1 Analogue Therapy in Postcolectomy Enteritis With High Output Stoma
Zachary Tuttle1,2, Emily Wright1,2, Mark Lust1,2
1Department of Gastroenterology, St Vincent's Hospital, Melbourne, Australia.
None:
Postcolectomy enteritis is a rare but serious complication after colectomy for ulcerative colitis. We report the case of a 71-year-old man with acute severe ulcerative colitis who developed steroid-refractory postcolectomy enteritis after subtotal colectomy with end ileostomy. Postoperatively, he experienced persistent high output stoma and ongoing ileal inflammation despite treatment with corticosteroids, infliximab, upadacitinib, and octreotide. Induction therapy with ustekinumab led to gradual endoscopic, histological, and radiological improvement. Off-label use of a glucagon-like peptide-1 analogue was initiated for the management of high output stoma, with subsequent reduction in stoma losses and successful weaning from parenteral nutrition.
Related Concept Videos
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Drugs for Treatment of Constipation-Predominant IBS
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Drugs for Treatment of Ulcerative Colitis in IBD
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

