Electronic Manipulation-Controlled Release Strategy-Driven Signal Off-On Mode for Ultrasensitive Detection of
Haorui Li1, Xianzhen Song1, Lu Zhao1,2
1Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, Ministry of Education; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China.
ACS Sensors
|July 13, 2026
Summary
A novel sensor detects Microcystin-LR (MC-LR) using electronic manipulation and controlled release. This method offers highly sensitive and rapid detection of freshwater toxins.
Area of Science:
- Environmental Science
- Analytical Chemistry
- Materials Science
Background:
- Microcystin-LR (MC-LR) is a prevalent freshwater toxin.
- Extrinsic electronic properties offer efficient signal response for sensing applications.
- Developing sensitive and rapid detection methods for MC-LR is crucial for environmental monitoring.
Purpose of the Study:
- To develop a highly sensitive sensor for MC-LR detection.
- To integrate electronic regulation and controlled release strategies for enhanced sensing performance.
- To utilize mesoporous silica nanoparticles (MSNs) for controlled release of glutathione (GSH).
Main Methods:
- Fabrication of a sensor using mesoporous silica nanoparticles (MSNs) loaded with glutathione (GSH).
- Utilizing DNA strands and antigens for antibody-specific triggering of GSH release via restriction enzyme DPN1.
- Employing a MnO2 QDs-CBMAA (M-CB) hydrogel substrate with antifouling and signal quenching capabilities.
- Implementing an electronic manipulation strategy where released GSH reduces MnO2 QDs, recovering the signal.
Main Results:
- The sensor achieved a low limit of detection (LOD) of 8.56 fg/mL for MC-LR.
- A broad detection range was established, from 10 fg/mL to 100 ng/mL.
- The integrated approach demonstrated rapid and highly efficient signal response.
Conclusions:
- The developed sensor provides a feasible method for sensitive trace detection of MC-LR.
- The novel electronic manipulation strategy enhances sensor performance.
- This approach offers a promising tool for environmental pollutant monitoring.
