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Bibliometric and Two-Sample Mendelian Randomization Analyses of the Causal Relationship Between Hypertension and
Jisheng Wang1, Sheng Deng2, Fei Teng3
1Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine.
Journal of Visualized Experiments : Jove
|July 13, 2026
Summary
Hypertension causes erectile dysfunction. Bibliometric analysis and Mendelian randomization confirm hypertension
Area of Science:
- Cardiovascular Medicine
- Urology
- Bibliometrics
Background:
- Hypertension (HT) is a prevalent condition often associated with erectile dysfunction (ED).
- Understanding the relationship between HT and ED is crucial for patient management.
- Existing research requires systematic analysis to identify trends and causal links.
Purpose of the Study:
- To systematically analyze and visualize publications on HT-related ED using bibliometrics.
- To identify key topics, research hotspots, and knowledge gaps in the field.
- To explore the causal relationship between HT and ED using Mendelian randomization (MR).
Main Methods:
- Bibliometric analysis of literature from Web of Science Core Collection (2001-2025).
- Mendelian randomization (MR) using single-nucleotide polymorphisms associated with HT.
- Inverse variance weighting, MR-Egger, and weighted median methods for MR analysis, with sensitivity analyses.
Main Results:
- 1,661 articles published between 2001 and 2025, with dominant contributions from Europe and North America.
- Key topics include nitric oxide, metabolic syndrome, and endothelial dysfunction.
- MR analysis confirmed a significant positive causal effect of HT on ED risk.
Conclusions:
- Bibliometrics reveals global research trends and collaboration networks in HT-related ED.
- Mendelian randomization provides robust evidence for a causal link between hypertension and erectile dysfunction.
- This study offers a comprehensive framework for understanding HT-related ED, supplementing observational data.
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