Related Experiment Video
Updated: Jul 15, 2026

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
Published on: July 10, 2017
Excision in Reduced Dimensionality: Synthesis of 1D Covalent Organic Framework via Clip-off Chemistry
Tongyan Li1, Ai-Juan Li2, Zichen Cai1
1Beijing Key Laboratory For Science and Application of Functional Molecular and Crystalline Materials, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
Abstract:
Synthesizing 1D COFs with a tailored chain stacking model is a significant challenge. Here, we introduce a novel preparation approach of 1D COFs involving selective excision from 2D matrix via clip-off chemistry. We carefully designed a 2D sql framework incorporating strategically cleavable olefinic linkers, enabling transformation of X-shaped tetratopic linkers into V-shaped ditopic counterparts through ozonolysis. The resulting 1D COF, featuring carboxyl group, was then functionalized with Anderson-type POMs via Schiff base reactions. This POM-COF composite demonstrated enhanced photocatalytic aldehyde oxidation, benefiting from synergistic effects to achieve efficient and selective conversion of aldehydes to carboxylic acids. Our work offers valuable insights for the custom synthesis of 1D COFs with predefined chain arrangements and functional orientations.
Related Concept Videos
Newman Projections
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as conformers.
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview
Acid Halides to Alcohols: LiAlH4 Reduction
The mechanism proceeds in three steps. First, the nucleophilic hydride ion attacks the carbonyl carbon of the acid halide to form a tetrahedral intermediate. Next, the carbonyl group is re-formed, and the halide ion departs as a leaving group, generating an aldehyde. A second nucleophilic attack by the hydride yields an alkoxide ion, which, upon protonation, gives a primary alcohol as...
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement
Amides to Amines: LiAlH4 Reduction
Amide reduction requires two equivalents of the reducing agent, acting as a source of hydride ions. As shown in the figure, the reaction is initiated with a nucleophilic attack by the hydride ion at the carbonyl carbon to form a tetrahedral intermediate.
Fischer Projections

