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Related Experiment Video

Updated: Jul 15, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Ovarian hyperstimulation syndrome: severity predictors.

Magdalena Piróg1, Olga Kacalska-Janssen1, Alicja Ogiegło1

  • 1Gynecological Endocrinology Department, Jagiellonian University Medical College, Krakow, Poland.

JBRA Assisted Reproduction
|July 13, 2026
PubMed
Summary

Elevated estradiol levels are linked to ovarian hyperstimulation syndrome (OHSS) severity. Lower albumin, total protein, and higher hematocrit predict severe OHSS, impacting pregnancy outcomes.

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Area of Science:

  • Reproductive endocrinology and infertility.
  • Clinical laboratory science.

Background:

  • Ovarian hyperstimulation syndrome (OHSS) is a significant risk in controlled ovarian hyperstimulation (COH).
  • Factors like elevated antral follicle count (AFC), anti-Mullerian hormone (AMH), and estradiol (E2) increase OHSS risk.

Purpose of the Study:

  • To identify clinical and laboratory markers of OHSS severity.
  • To evaluate pregnancy outcomes in women hospitalized with moderate to severe OHSS.

Main Methods:

  • A cohort of 71 women with moderate (n=38) or severe (n=31) OHSS was analyzed.
  • Key laboratory parameters including E2, hemoglobin, hematocrit, creatinine, albumin, total protein, D-dimer, and ALT were measured.
  • Hospitalization duration and pregnancy outcomes were recorded.
Keywords:
albuminestradiolhematocritinfertilityovarian hyperstimulation syndrome

Related Experiment Videos

Last Updated: Jul 15, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Main Results:

  • Women with severe OHSS had significantly higher initial E2 and hematocrit levels, and lower albumin and total protein concentrations compared to those with moderate OHSS.
  • Pregnancy rates were lower in the severe OHSS group, with outcomes approximately half those in the moderate group.
  • Severe OHSS was associated with a 2.9-fold longer hospitalization period.

Conclusions:

  • Elevated serum estradiol concentration is a key factor associated with OHSS development during COH.
  • Basal serum albumin, total protein, and hematocrit levels are predictive of OHSS severity.
  • These parameters can aid in assessing OHSS risk and guiding patient management.