The current molecular landscape of endometrial and ovarian carcinomas: insights and practical updates

Gynecologic pathology is undergoing major changes in classification and diagnosis with recent advances in molecular pathology. Not only have advances allowed for refinement of diagnostic algorithms, but they have also translated into more targeted therapies for many patient groups. Molecular pathology is an area which necessitates ongoing review by the practicing pathologist, especially those in a multi-disciplinary setting. While the field of gynecologic pathology has many areas which are showing developments, a comprehensive review would span the length of a textbook. In this review article, the authors focus on two of the most common and therefore most applicable categories, endometrial and ovarian carcinoma. A review of the molecular underpinnings of recent developments is presented alongside new testing which is available to translate these findings into therapies for patients.