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Related Experiment Video

Updated: Jul 15, 2026

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Microstructure-centric ultrasonic evaluation of granular composite oral solid dosage tablets.

Tipu Sultan¹, Vivek S Dave², James Stephens³

¹Photo-Acoustics Research Laboratory, Clarkson University, Department of Mechanical and Aerospace Engineering, Potsdam, NY 13699-5725, USA.

International Journal of Pharmaceutics

|July 13, 2026

Summary

This study introduces an ultrasonic method to characterize the microstructure and microviscoelasticity of Oral Solid Dosage (OSD) forms. The technique enables real-time release testing by analyzing wave dispersion and attenuation in pharmaceutical products.

Keywords:

Compressed Oral Solid Dosage (OSD)Continuous Manufacturing (CM)Critical Quality Attributes (CQAs)Granular composites Material Attributes (MAs)Microstructure-centric micro-viscoelastic characterization Process Analytical Technology (PAT)Process Parameters (PPs)Quality by Design (QbD)Real-Time Release Testing (RTRT)

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Last Updated: Jul 15, 2026

Formation of Dispersible Taohong Siwu Tablets

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Published on: February 3, 2023

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

Published on: March 12, 2014

Area of Science:

Pharmaceutical Sciences
Materials Science
Acoustics

Background:

Oral Solid Dosage (OSD) forms possess complex microstructures critical for quality attributes.
Understanding microstructural mechanics and viscoelasticity is key to controlling drug release.
Current models for ultrasonic wave propagation in granular media are limited.

Purpose of the Study:

To develop a quantitative understanding of compact microstructure and microviscoelasticity in OSD forms.
To establish a framework for characterizing granular media using ultrasonic elastic pulses.
To enable non-destructive, real-time analysis of OSD properties.

Main Methods:

Utilized high-frequency, short-wavelength ultrasonic elastic pulses.
Developed a deterministic framework coupling Zener micro-viscoelasticity with Rayleigh scattering.
Analyzed frequency-dependent longitudinal-wave attenuation and dispersion in OSD compacts.

Main Results:

Demonstrated a novel ultrasonic methodology for microstructural and viscoelastic characterization.
The framework successfully models granularity and viscoelastic losses.
The method provides a non-destructive, volumetric probe of internal OSD properties.

Conclusions:

The developed ultrasonic methodology is cost-effective, computationally efficient, and scalable.
This approach supports rapid Real-Time Release Testing (RTRT) of OSD forms.
The study advances the understanding of elastic wave propagation in viscoelastic granular media.