Related Experiment Video
Updated: Jul 15, 2026
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
Published on: March 18, 2014
Efficacy of combined photodynamic therapy and Mohs micrographic surgery for facial squamous cell carcinoma: A
Xurong Liu1, Zhanji Pang1, Jianjin Liu1
1Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Background:
Facial squamous cell carcinoma (SCC) presents significant therapeutic challenges due to high recurrence risks in aesthetically and functionally critical areas. While Mohs micrographic surgery (MMS) remains the gold standard for tissue conservation and margin control, adjuvant therapies may further mitigate recurrence.
Objective:
This study aims to evaluate the clinical efficacy of combining MMS with Photodynamic Therapy (PDT) compared to MMS monotherapy for facial SCC.
Methods:
A retrospective analysis of 108 patients was conducted. Subjects were categorized into two cohorts: MMS alone (n = 16) and MMS+PDT (n = 92). Adjuvant PDT utilized 20 % topical 5-aminolevulinic acid (ALA, solution; Shanghai Fudan-Zhangjiang Bio-Pharmaceutical) incubated for 3 h, followed by 630 nm red LED irradiation (37 J/cm²). The primary endpoint was Recurrence-Free Survival (RFS). Statistical methods included Kaplan-Meier analysis and Multivariable Cox Proportional Hazards regression.
Results:
The recurrence rate was significantly higher in the MMS monotherapy group (18.8 %) compared to the MMS+PDT group (7.6 %). Multivariable Cox regression, adjusting for age and gender, demonstrated that the combination of MMS+PDT significantly reduced the hazard of recurrence (HR=0.159, 95 % CI: 0.035-0.722, P = 0.017). The mean RFS for the combination group was 44.3 ± 7.3 months compared to 34.4 ± 6.7 months for MMS alone. Adjuvant PDT increased transient localized toxicities, most notably mild-to-moderate transient erythema (93.5 %) and intra-procedural pain(81.5 %). No serious systemic adverse events or permanent treatment discontinuations due to toxicities were recorded.
Conclusion:
Adjuvant PDT following MMS significantly enhances RFS in patients with facial SCC, offering a superior protective effect against recurrence compared to surgical intervention alone.
