Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Folliculogenesis01:20

Folliculogenesis

Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying Sources of Black Carbon Associated with High Mortality Risk in Beijing, China Based on Long-term Hourly Continuous Measurements.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Multi-compartment immune and tumor cell reprogramming by IFNα2 overcomes colon cancer immunotherapy resistance.

bioRxiv : the preprint server for biology·2026
Same author

Identifying Tracing Species from Source Regions of PM<sub>2.5</sub> on the Tibetan Plateau by Integrating Measurement and Modeling.

Environmental science & technology·2026
Same author

Electron-Phonon Coupling in Weakly Quantum-Confined Perovskite Nanocrystals.

ACS nano·2026
Same author

Structurally Defined Low-Coordination Single-Atom Strategy for CO<sub>2</sub> Photoconversion to Formic Acid.

Journal of the American Chemical Society·2026
Same author

DKK3-CKAP4 signaling drives fibroimmune remodeling and hair follicle miniaturization in androgenetic alopecia.

Theranostics·2026

Related Experiment Video

Updated: Jul 15, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
05:32

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

Follicle-stimulating hormone and cancer.

Yaohua Li1, Yuexin Liu1, Yang Guo1

  • 1Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Diseases & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China.

Cellular Signalling
|July 13, 2026
PubMed
Summary

Follicle-stimulating hormone receptor (FSHR) signaling is implicated in cancer, but its role varies by tumor type and location. Further research and standardization are needed for therapeutic applications.

Keywords:
Cancer progressionEpithelial-mesenchymal transition (EMT)Follicle-stimulating hormone (FSH)Follicle-stimulating hormone receptor (FSHR)Metabolic reprogrammingNanomedicine

More Related Videos

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
06:36

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion

Published on: April 24, 2015

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

Related Experiment Videos

Last Updated: Jul 15, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
05:32

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
06:36

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion

Published on: April 24, 2015

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Follicle-stimulating hormone (FSH) and its receptor (FSHR) are key in reproduction.
  • Emerging evidence suggests FSH-FSHR signaling influences cancer development.
  • The role of FSHR in cancer is context-dependent and requires detailed investigation.

Purpose of the Study:

  • To review and grade evidence linking FSH-FSHR signaling to various cancer types.
  • To differentiate the roles of tumor-cell FSHR and vascular FSHR.
  • To evaluate diagnostic and therapeutic strategies targeting FSHR in cancer.

Main Methods:

  • Systematic review of existing literature on FSHR in cancer.
  • Categorization of evidence by tumor type.
  • Analysis of FSHR expression in tumor cells versus vasculature.
  • Evaluation of detection methods, nanomedicine, and imaging approaches.

Main Results:

  • FSH-FSHR signaling impacts cancer proliferation, EMT, metabolism, stemness, and metastasis.
  • Evidence is strongest for ovarian cancer, with mixed findings in other tumor types.
  • Distinguishing tumor-cell FSHR from vascular FSHR is crucial for mechanistic and therapeutic understanding.

Conclusions:

  • FSHR plays a complex, context-dependent role in cancer biology.
  • Standardization of FSHR detection and clinical validation are essential for therapeutic translation.
  • Further research is needed to refine FSHR-targeted nanomedicine, imaging, and safety profiles.