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Updated: Jul 15, 2026

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo
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High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

Published on: November 8, 2018

Agreement between Mid-pregnancy Serum Placental Growth Factor Levels and Abnormalities in Uterine Doppler Ultrasound

Adelaide Burrows1, Jennifer A Hutcheon1, Eda Karacebeyli1

  • 1Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|July 13, 2026
PubMed

This prospective observational study evaluated the concordance between mid-pregnancy serum placental growth factor (PlGF) levels and abnormal uterine artery Doppler findings in pregnancies at risk of placental insufficiency. Among 127 patients, PlGF testing was discordant with uterine artery Doppler findings in 17% of cases with minimal agreement (κ 0.07; 95% CI -0.13 to 0.28), and only 2 of 10 patients with abnormal uterine artery Doppler had low PlGF. These findings suggest that PlGF and uterine artery Doppler identify different at-risk populations and should not be used interchangeably in placental risk stratification.

Keywords:
Doppler ultrasonographyfetal growth retardationplacental growth factorplacental insufficiencypreeclampsiauterine artery

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