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Updated: Jul 15, 2026
Transvaginal Mesh Insertion in the Ovine Model
Published on: July 27, 2017
Human Acellular Dermal Matrix Versus Polypropylene Mesh in Pelvic Floor Reconstruction: A Retrospective Study on
Yuhan Sun1, Qinghua Qu1, Lu Jiang1
1Department of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing, China; Department of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, China; NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing, China; Chongqing Key Laboratory of Human Embryo Engineering and Precision Medicine, Chongqing, China.
Objectives:
To compare surgical outcomes and sexual quality of life following pelvic floor reconstruction using human acellular dermal matrix (ADM) versus polypropylene mesh (PM).
Methods:
This retrospective study included patients with anterior compartment and uterine prolapse who underwent transvaginal anterior sacrospinous ligament fixation between September 2021 and July 2023. Patients were grouped by graft type: ADM (n = 16) or PM (n = 25). Primary outcomes included operative data, complications, Pelvic Organ Prolapse Quantification (POP-Q) scores, and quality-of-life questionnaires (PFDI-20, PFIQ-7, PISQ-12) at 3 and 12 months postoperatively.
Results:
Both groups showed significant postoperative improvements in POP-Q parameters and functional scores compared to baseline (P < 0.05). No significant differences were found between groups regarding blood loss, complication rates, or recurrence. The ADM group required significantly longer operative time than the PM group (88.06 vs. 61.68 minutes, P < 0.05). Postoperative dyspareunia was lower in the ADM group (7.7%) compared to the PM group (20%), though this difference was not statistically significant.
Conclusions:
Both ADM and PM provide comparable anatomical success and improved patient well-being in pelvic floor reconstruction. ADM may offer advantages in preserving sexual function by reducing dyspareunia, although larger multicenter studies are needed to confirm these findings.
