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Prognostic Factors in Primary Submandibular Gland Carcinoma: A Systematic Review and Meta-analysis
Eray Uzunoğlu1, Sevilay Karahan2, Tankut Uzun1
1Assisstant Professor, MD, Department of Otorhinolaryngology/Head and Neck Surgery, Çiğli Training and Research Hospital, Bakırçay University, İzmir, Turkey.
Summary
Advanced T and N stages are key adverse prognostic factors for overall survival in primary submandibular gland carcinoma. These findings aid in risk stratification and treatment planning for this rare cancer.
Area of Science:
- Oncology
- Head and Neck Surgery
- Salivary Gland Cancer Research
Background:
- Primary submandibular gland carcinoma is a rare malignancy with significant morbidity and mortality.
- Limited and heterogeneous data hinder understanding of prognostic factors and optimal management.
Purpose of the Study:
- To synthesize existing evidence on prognostic factors influencing survival in primary submandibular gland carcinoma.
- To identify key predictors of overall survival for improved clinical decision-making.
Main Methods:
- Systematic literature search of PubMed, Scopus, and Web of Science.
- Meta-analysis of 24 eligible studies (5,050 subjects) using random-effects models.
- Data extraction included demographics, histology, clinicopathologic variables, treatment, and survival outcomes.
Main Results:
- Advanced T stage (logHR=0.88, P=.04) and N stage (logHR=1.29, P=.002) were significantly associated with worse overall survival (OS).
- Adenoid cystic carcinoma was the most frequent subtype (37.6%).
- Age, sex, grade, invasion, and adjuvant radiotherapy did not significantly impact OS.
Conclusions:
- Advanced T and N stages are principal adverse prognostic factors for OS in submandibular gland carcinoma.
- These findings underscore the importance of thorough primary tumor and neck assessment for risk stratification and treatment planning.