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Related Concept Videos

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...

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Updated: Jul 15, 2026

Optimization for Sequencing and Analysis of Degraded FFPE-RNA Samples
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[Effect of RNA Sequencing Normalization on Forensic Age Estimation].

Jinyuan Zhao1,2, Yujia Xuan1,2, Anqi Chen2

  • 1Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot 010110, China.

Fa Yi Xue Za Zhi
|July 13, 2026
PubMed
Summary

The trimmed mean of M-values (TMM) normalization method significantly improves RNA sequencing accuracy for forensic age estimation. This method is recommended for developing precise age prediction models.

Area of Science:

  • Forensic Science
  • Genomics
  • Bioinformatics
Keywords:
RNA sequencingage estimationforensic geneticsmachine learningnormalization

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