Related Experiment Video
Updated: Jul 15, 2026

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
Published on: September 12, 2025
[Burkitt lymphoma: Definition, diagnostic approach, and current therapeutic strategies]
Morgane Gonin1, Carolyne Croizier2, Hédi Bensaber1
1Service de thérapie cellulaire et hématologie clinique adulte, CHU Estaing, Clermont-Ferrand, France.
Abstract:
Burkitt lymphoma is a rare and highly aggressive B-cell disorder characterized by rapid proliferation, and a translocation involving the c-MYC gene. It affects patients of all ages. The association with Epstein-Barr virus is well established in the 2022 World Health Organization classification, which identifies two molecular subtypes independent of epidemiological context. Diagnosis relies on a combination of clinical, histological, and cytogenetic features, allowing differentiation from other high-grade B-cell lymphomas. Prompt therapeutic management is crucial. Frontline therapy is based on intensive chemo-immunotherapy regimens, including anti-CD20 monoclonal antibodies. In young patients, overall survival rates reach 80-90%. Poor prognosis is mainly observed in refractory or relapsed disease. Emerging therapeutic approaches such as cellular therapy (genetically modified T-cell receptor therapies), immunotherapy (bispecific antibodies), and targeted therapy - currently approved in other B-cell lymphomas, are under investigation in Burkitt lymphoma. This review summarizes the definition, historical background, diagnostic criteria, classification, and current therapeutic management of Burkitt lymphoma in 2025.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Tumor Immunotherapy
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)