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Published on: November 28, 2019
Microbial bile acids: Immunomodulatory signals in the tumor microenvironment
Shuyi Mi1, Qiwen Wang1, Dingjiacheng Jia1
1Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province 310058, China; Institution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.
None:
Microbial metabolites can act as systemic signals that connect gut dysbiosis to tumor immune remodeling. Recently, Li et al. showed that gut microbiota-derived deoxycholic acid activates the farnesoid X receptor-nuclear factor κB-interleukin-6 axis in breast cancer cells, promoting the recruitment of granulocytic myeloid-derived suppressor cells, T helper polarization, and tumor progression. These findings offer new insights into microbial bile acid signaling in the tumor microenvironment.
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