Related Experiment Video
Updated: Jul 15, 2026

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
Published on: July 17, 2016
Testosterone and anabolic androgenic steroids: Impact on acute kidney injury
Manuel Heras Benito1, Celia Rodríguez Tudero2
1Servicio de Nefrología, Hospital Universitario de Salamanca, Salamanca, Spain; Facultad de Medicina, Universidad de Salamanca, Salamanca, Spain.
Abstract:
The synthesis of testosterone and its modifications have allowed its use in treating medical conditions of hormonal deficiency. Currently, the most common use of anabolic-androgenic steroids (AAS)-synthetic testosterone derivatives-is for purposes other than medical treatment. Various complications have been reported among AAS users, with cardiovascular and hepatic complications being the best documented; direct renal toxicity is less well understood. AAS-associated acute kidney injury (AKI-AAS) is an emerging entity, resulting from the increased number of reported cases and greater use of these agents, although its true prevalence is unknown. Analysis of clinical cases suggests that the main mechanisms involved in AKI-AAS are indirect. This review examines the main mechanisms of kidney injury in users of these agents.
Related Concept Videos
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury I: Introduction
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury VI: Nursing Management
