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Related Concept Videos

Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...

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Related Experiment Video

Updated: Jul 15, 2026

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
05:46

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

Published on: June 9, 2020

Next-generation kidney tissue analysis - spatial omics and digital pathology.

Takahisa Yoshikawa1, Roman D Bülow2, Peter Boor3,4,5

  • 1Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Nature Reviews. Nephrology
|July 13, 2026
PubMed
Summary

Spatial omics and advanced imaging offer new ways to study kidney tissue organization and cellular interactions. This approach promises to improve kidney disease diagnosis, biomarker discovery, and therapeutic development.

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Last Updated: Jul 15, 2026

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

Area of Science:

  • Nephrology
  • Pathology
  • Genomics

Background:

  • Kidney diseases require detailed pathological analysis of tissue samples.
  • Current non-spatial omics methods lack crucial spatial context for understanding cell interactions.
  • Kidney's complex cellularity and architecture necessitate spatial analysis.

Purpose of the Study:

  • To highlight the importance of spatial omics and imaging in kidney disease research.
  • To explore the integration of spatial omics with computational pathology.
  • To identify potential applications in diagnostics, biomarker discovery, and drug development.

Main Methods:

  • Spatial omics technologies (e.g., transcriptomics, epigenomics, metabolomics).
  • Three-dimensional imaging technologies.
  • Computational pathology and pathomics.

Main Results:

  • Spatial omics enables simultaneous analysis of molecular profiles and spatial context.
  • Integration with imaging and computational pathology enhances understanding of pathophysiology.
  • These methods can reveal novel disease mechanisms and cellular interactions.

Conclusions:

  • Spatial omics and advanced imaging are crucial for deciphering kidney pathophysiology.
  • These integrated approaches hold promise for identifying diagnostic and prognostic biomarkers.
  • Future applications may include routine pathology diagnostics and drug discovery.