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Cellular reprogramming and signaling control by kaempferol in colorectal cancer
1Health College, Binzhou Polytechnic University, Binzhou, 256603, Shandong, China.
Abstract:
Drug resistance and toxicity are major challenges for colorectal cancer (CRC) therapy. Kaempferol (KMP), a natural flavonoid compound, is characterized by low toxicity and multi-targeted effects. KMP has multiple biological functions (anti-inflammation, antioxidation, anti-angiogenesis, apoptosis induction, and immunoregulation). Therefore, KMP is extensively investigated the treatment of various diseases, including cancer. Currently, a series of studies has explored the potential anti-cancer role in CRC therapy. KMP can inhibit the progression of colitis to CRC. Furthermore, KMP suppresses the proliferation of CRC cells and tumor growth. The mechanisms regulated by KMP are involved in multiple signaling pathways such as the matrix metalloproteinases family, VEGF/VEGFR, Wnt/β-catenin, and PI3K/Akt/mTOR. As a multi-targeted inhibitor, KMP shows its natural advantage in combination therapy and is often defined as a sensitizer or attenuator. However, due to the poor stability, absorption, and bioavailability of KMP, its clinical value is hindered. Nano-based delivery systems can compensate for these shortcomings and boost their therapeutic potential. KMP is a hopeful anticancer flavonol, and this review aims to summarize its anticancer effects, mechanisms, and potential applications in CRC.
Insights
Kaempferol (KMP), a natural compound, shows promise in treating colorectal cancer (CRC) by inhibiting tumor growth and proliferation. However, its clinical use is limited by poor bioavailability, suggesting nano-delivery systems could enhance its therapeutic potential.
Area of Science:
- Oncology
- Pharmacology
- Natural Products Chemistry
Background:
- Colorectal cancer (CRC) presents significant therapeutic challenges due to drug resistance and toxicity.
- Kaempferol (KMP), a natural flavonoid, exhibits low toxicity and diverse biological activities, including anti-inflammatory, antioxidant, anti-angiogenic, and apoptosis-inducing effects.
- KMP has demonstrated potential in preclinical studies for various diseases, including cancer therapy.
Purpose of the Study:
- To review the anticancer effects and mechanisms of Kaempferol (KMP) in colorectal cancer (CRC) therapy.
- To explore the potential of KMP as a therapeutic agent and sensitizer in CRC treatment.
- To discuss the limitations of KMP, such as poor bioavailability, and the potential of nano-based delivery systems.
Main Methods:
- Literature review of studies investigating Kaempferol's role in colorectal cancer.
- Analysis of KMP's effects on CRC cell proliferation, tumor growth, and colitis-CRC progression.
- Examination of signaling pathways modulated by KMP, including MMPs, VEGF/VEGFR, Wnt/β-catenin, and PI3K/Akt/mTOR.
Main Results:
- KMP inhibits CRC cell proliferation and tumor growth.
- KMP can prevent the progression of colitis to CRC.
- KMP modulates multiple cancer-related signaling pathways, acting as a multi-targeted inhibitor.
Conclusions:
- Kaempferol (KMP) is a promising natural compound for colorectal cancer (CRC) therapy due to its multi-targeted anticancer effects.
- KMP's clinical application is hindered by poor stability, absorption, and bioavailability.
- Nano-based delivery systems offer a potential strategy to overcome KMP's limitations and enhance its therapeutic efficacy in CRC treatment.
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