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Early Dysglycemia Detected by Continuous Glucose Monitoring in a 6-Year-Old Child with Cystic Fibrosis: A Case Report

Busra Baspinar1, Merve Nur Tekin2, Ayşe Özfer Özçelik3

  • 1Department of Nutrition and Dietetics, Faculty of Health Sciences, Erzincan Binali Yıldırım University, Erzincan, Türkiye.

Pediatric Allergy, Immunology, and Pulmonology
|July 14, 2026
PubMed

Insights

Continuous glucose monitoring (CGM) can detect early signs of cystic fibrosis-related diabetes (CFRD) in young children, enabling timely intervention. This method identifies glucose abnormalities missed by conventional screening, improving outcomes for pediatric cystic fibrosis patients.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Respiratory Medicine

Background:

  • Cystic fibrosis-related diabetes (CFRD) screening typically starts at age 10.
  • Glucose abnormalities can manifest earlier in pediatric cystic fibrosis (CF) patients.
  • Conventional screening tools may not detect early dysglycemia in young children with CF.

Purpose of the Study:

  • To evaluate the utility of continuous glucose monitoring (CGM) in detecting dysglycemia in a young child with CF.
  • To assess if CGM can identify glucose metabolism issues missed by standard screening methods in pediatric CF.

Main Methods:

  • A 6-year-old girl with CF underwent 14-day continuous glucose monitoring (CGM).
  • The study focused on glucose metabolism in pediatric CF patients.
  • Laboratory workup included glycated hemoglobin (HbA1c) measurement.

Main Results:

  • CGM revealed significant glycemic variability (38.4%) and a mean glucose of 192 mg/dL.
  • Despite mild fasting hyperglycemia, CFRD was confirmed (HbA1c 8.8%).
  • Pulmonary function improved significantly after insulin initiation (FEV increased from 76% to 97%).

Conclusions:

  • CGM can identify significant dysglycemia in young CF patients below the standard screening age.
  • Early detection via CGM may lead to timely intervention and improved clinical outcomes.
  • Prospective studies are warranted to confirm CGM's role in high-risk pediatric CF patients.

Keywords:
case reportcontinuous glucose monitoringcystic fibrosiscystic fibrosis–related diabetespediatric dysglycemia

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