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Updated: Jul 15, 2026
05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Hormones, hormesis, and holistic obesity care
Sanjay Kalra1, Shinjan Patra2, Lakshmi Nagendra3
1Department of Endocrinology, Bharti Hospital, Karnal, India; University Center for Research & Development, Chandigarh University, India.
JPMA. the Journal of the Pakistan Medical Association
|July 14, 2026
Summary
Hormones are chemical messengers, while hormesis is a low-dose beneficial stress response. This commentary explores the link between obesity hormones and hormesis in areas like reproductive health, bone health, and diabetes.
Area of Science:
- Endocrinology
- Biology
- Homeostasis
Background:
- Hormones act as chemical messengers for inter-organ and inter-cellular communication.
- Hormesis describes a biphasic dose-response where low stressor doses yield benefits, while high doses are detrimental.
- Hormesis is recognized in plant and animal biology and various medical fields.
Purpose of the Study:
- To elucidate the connection between obesity-related hormones and the hormesis phenomenon.
- To simplify the concept of hormesis by illustrating its link with endocrine regulation in obesity.
- To explore practical applications and implications of this relationship.
Main Methods:
- This is a commentary, not an experimental study.
- It synthesizes existing knowledge on hormones and hormesis.
- Examples from reproductive endocrinology, bone health, and diabetes are used for illustration.
Main Results:
- Obesity involves dysregulation of hormones that can interact with hormetic pathways.
- Low-dose exposures relevant to hormesis may influence obesity-related hormonal signaling.
- Understanding this interplay can offer new perspectives on metabolic and endocrine disorders.
Conclusions:
- The relationship between obesity hormones and hormesis offers a novel framework for understanding health and disease.
- Further research into hormetic effects on endocrine systems in obesity is warranted.
- This concept may inform therapeutic strategies targeting metabolic and hormonal imbalances.
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