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Association of C-Reactive Protein-Triglyceride Glucose Index and TyG Index With Prehypertension and Hypertension

Shijie Yang1, Yuqing Zhang2, Zhanyang Zhou2

  • 1AnZhen Hospital of the Capital University of Medical Sciences, Beijing, China.

Immunity, Inflammation and Disease
|July 14, 2026
PubMed

Insights

The C-reactive protein-triglyceride glucose index (CTI) and triglyceride-glucose (TyG) index are linked to higher hypertension risk in older Chinese adults. CTI shows better early risk detection for hypertension.

Area of Science:

  • Cardiovascular Disease Epidemiology
  • Metabolic Syndrome Research
  • Biomarker Discovery

Background:

  • Hypertension is a major global health concern, particularly in aging populations.
  • Early identification of hypertension risk factors is crucial for effective prevention strategies.
  • The triglyceride-glucose (TyG) index is a recognized marker of insulin resistance and cardiovascular risk.

Purpose of the Study:

  • To investigate the association between the C-reactive protein-triglyceride glucose index (CTI) and the triglyceride-glucose (TyG) index with prehypertension and hypertension.
  • To evaluate the predictive performance of CTI and TyG for hypertension in a Chinese population aged 45 and older.
  • To compare the responsiveness of CTI and TyG in identifying hypertension risk.

Main Methods:

  • Cross-sectional study involving 8389 Chinese adults aged 45 years and older.
  • Participants were categorized into normotensive, prehypertensive, and hypertensive groups based on blood pressure.
  • Multivariate logistic regression and restricted cubic spline (RCS) analyses were used to assess the associations and dose-response relationships.

Main Results:

  • Both the highest quartiles of CTI and TyG indices were significantly associated with an increased risk of hypertension (ORs ≈ 1.59).
  • Similar independent associations were found for prehypertension.
  • CTI demonstrated enhanced responsiveness, showing a significant association with hypertension even at lower exposure levels (Q2) and a stronger non-linear dose-response relationship compared to TyG.

Conclusions:

  • CTI and TyG index are independent predictors of prehypertension and hypertension in middle-aged and elderly Chinese adults.
  • CTI may serve as a valuable, cost-effective tool for early hypertension risk stratification due to its responsiveness.
  • While modest in standalone discriminatory power, CTI's sensitivity to non-linear risk transitions warrants further investigation.

Keywords:
C‐reactive protein‐triglyceride glucose indexTriglyceride‐glucose indexanthropometric indicatorhypertensionprehypertension

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