Mechanical capture, protection and interconversion of cyclodextrins in redox-responsive enzyme-catalysed dynamic
Kasper H Hansen1, Sophie R Beeren1
1Department of Chemistry, Technical University of Denmark, Kemitorvet Building 207, Kongens Lyngby 2800, Denmark. sopbee@kemi.dtu.dk.
None:
Redox-controlled rotaxane formation can be employed as a novel strategy for cyclodextrin interconversion via a process of template-directed enzymatic synthesis, mechanical capture and release. Mechanical bonds are shown to protect cyclodextrins from hydolysis by α-amylase and cyclodextrin glucanotransferase, facilitating rotaxane isolation and enabling size-selective separation of cyclodextrins via reversible rotaxane formation.
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